Aberrant ubiquitination is a potential pathogenic mechanism in amyotrophic lateral sclerosis

Takeaway

  • Novel susceptibility genes for amyotrophic lateral sclerosis (ALS), TYW3/CRYZ and FGD4, are associated with insulin resistance and Charcot-Marie Tooth disease, respectively.

  • Ubiquitin-C (UBC) is a central hub in the network of ALS-associated genes.

Why this matters

    The identification of novel causative genes may help uncover unknown pathogenic mechanisms and potential therapeutic targets for the treatment of ALS.