Amyloid-β, tau and low-density lipoprotein receptor-associated protein in Alzheimer’s Disease

Takeaway

  • Decreased levels of low-density lipoprotein receptor-associated protein (RAP) correlate with increased levels of amyloid-β (Aβ) and tau accumulation in neuropathological tissue samples from people with Alzheimer’s Disease (AD).

Why this matters

  • Key neuropathological features of AD include Aβ and tau protein accumulation; animal models of AD have shown correlations between these measures and levels of RAP in brain tissue.

    A potential role for RAP in the pathological process of AD in humans has important implications for the development of targeted treatments for AD, which could significantly impact patient outcomes.