Biomarker classification system stratified risk for progression to cognitive decline and dementia

Takeaway

  • Dementia risk in people experiencing subjective cognitive decline was heightened for those with a biomarker for β-amyloid; dementia risk was further increased for those with biomarkers for tau and neurodegeneration.

Why this matters

    These findings indicate the amyloid, tau, neurodegeneration (ATN) classification system could be used for individualized risk profiling in clinically normal people.