Brainstem pain modulation circuitry is altered in migraine sufferers

Takeaway

  • Brainstem pain modulation circuitry is altered throughout the migraine cycle, but this study demonstrated reduced pain sensitivity prior to migraine onset, contrary to previous reports.

Why this matters

  • Pain sensitivity fluctuations and corresponding alterations in brainstem pain modulation circuitry among migraine sufferers may reflect the altered neural states required for generation of a migraine.