Diffusion tensor imaging method detects white matter changes in preclinical Alzheimer’s disease

Takeaway

  • Diffusion tensor imaging (DTI) processed with wavelet connectivity signature (WaCS) techniques can identify changes in white matter structure associated with Alzheimer’s disease (AD), and these changes are correlated with biomarkers of neurodegeneration measured in cerebrospinal fluid (CSF).

Why this matters

  • Longitudinal changes in white matter in AD are poorly characterized, especially in the asymptomatic, preclinical stage of the disease, and non-invasive methods of detecting changes in brain structure may facilitate earlier disease diagnosis and treatment monitoring.