Distinguishing white matter pathologies in Alzheimer’s disease

Takeaway

  • White matter heterogeneity expressed in the form of a temporal/frontal factor, a parietal factor, and a long fibre bundle factor contributes to the pathology of Alzheimer’s disease (AD).

Why this matters

  • AD is immensely complex and often heterogenous in its structural and pathological underpinnings; while impairments in white matter (WM) are also present in people with AD, details regarding the extent of WM heterogeneity are still sparse.