Baseline microglial activation predicts cognitive decline in Alzheimer disease (AD).
Why this matters
It is unclear whether neuroinflammation is associated with amyloidosis and cognitive decline in AD.
Microglia are involved in neuroinflammatory responses in AD pathologies of amyloid and tau. [11C]PK11195, a PET radiotracer, binds to a microglial protein 18-kDa translocator protein, to assess the microglial activation in AD.