Identification of two epitope markers which predict multiple sclerosis in optic neuritis patients

Takeaway

  • This pilot study on epitope diagnostics for multiple sclerosis (MS) identifies novel immunological disease features using unbiased mimotope variation analysis (MVA).

Why this matters

  • Optic neuritis (ON) can occur in isolation or develop into MS; however, predictive factors of this progression remain poorly understood, as do the central nervous system (CNS) antigens targeted by T and B cells in MS.

  • The identification of novel disease features highlights the importance of understanding immunoreactivity at the epitope level in MS to aid current and future efforts towards personalized treatment development.