Identifying plasma biomarkers for epilepsy diagnosis

Takeaway

  • A combination of four proteins are modulated in the 24 hours following an epileptic seizure (ES), providing a clear plasma biomarker to distinguish ES from psychogenic non-epileptic seizures (PNES).

Why this matters

  • Accurate diagnosis of epilepsy is challenging, and misdiagnosis is common.

  • PNES can mimic ES and are commonly misdiagnosed as ES.

  • Neuroinflammation is highly associated with ES and could act as a differential biomarker for the diagnosis of ES vs PNES.