Idiopathic rapid eye movement sleep behavior disorder and cholinergic denervation

Takeaway

  • Reduced neocortical 11C -donepezil binding indicates cholinergic denervation in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD).

Why this matters

    iRBD is associated with an increased risk of Parkinson disease (PD) and dementia with Lewy bodies (DLB); the role of cholinergic dysfunction in the early stages of PD or DLB has not been investigated but may help to understand mechanisms underlying dementia development.