Summary Summary Short summary of a recent publication, written by scientific experts.

Loss of TREM2 impairs amyloid plaque clearance in Alzheimer’s Disease (AD)

Takeaway

  • Heterozygous or homozygous loss of TREM2, but not TREM+/R47H is associated with reduced amyloid plaque clearance and microglial characteristics, warranting further mechanistic study.

Why this matters

    Individuals with the TREM