M1 muscarinic acetylcholine receptor function is impaired in moderate Alzheimer’s disease

Takeaway

  • Muscarinic acetylcholine receptor dysfunction in moderate Alzheimer’s disease is caused by abnormal activation of the metabotropic glutamate receptor subtype 5.

Why this matters

    Muscarinic acetylcholine receptors are a potential disease-modifying target in the pathological stages of moderate Alzheimer’s disease; preventing acetylcholine-signaling could help to slow disease progression.

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