Marked connectivity changes in the brains of patients with pre-diagnosed primary lateral sclerosis

Takeaway

  • Distinct characteristics exist in the functional connectivity of patients with primary lateral sclerosis (PLS) pre-diagnosis, which may help with earlier detection.

Why this matters

  • The time-to-diagnosis for patients with PLS is currently 3–5 years, identifying PLS-related changes that occur in early disease may reduce this time.