Medication overuse and headache burden


  • Approximately two-thirds of respondents from the Chronic Migraine Epidemiology and Outcomes (CaMEO) study with acute medication overuse (AMO) did not meet criteria for medication overuse headache (MOH), reporting under 15 monthly headache days (MHDs).

Why this matters

  • MOH implies a causal link between medication overuse and headache, while AMO refers to use of specific medications ≥10 days per month or ≥15 days per month for simple analgesics; as such, some people with AMO may not meet headache day criteria for MOH.

  • The incidence of AMO and associated clinical features in migraine patients highlights the need for comprehensive migraine management plans that include improved acute treatment options and non-pharmacological techniques, with appropriate patient education.