Memory function is preserved in people with primary progressive aphasic Alzheimer’s disease

Takeaway

  • People with primary progressive aphasia-Alzheimer's disease have preserved memory function that persists for years despite hippocampo-entorhinal disease neuropathology.

Why this matters

    The primary progressive aphasic phenotype of Alzheimer's disease enables the exploration of distinct mechanisms underlying the impact of Alzheimer’s disease neuropathology on cognitive function. The findings suggest that asymmetry of mediotemporal atrophy and a smaller impact of Apolipoprotein E4 on memory circuitry integrity may underlie the observed resilience to memory loss in aphasic dementia and could represent a novel therapeutic target.