Parkinson’s disease: Association with Cardiovascular autonomic function and MCI

Takeaway

  • Mild cognitive impairment (MCI) is primarily associated with parasympathetic dysfunction rather than sympathetic function in Parkinson’s Disease (PD).

Why this matters

    By evaluating the presence of MCI, cardiovascular dysautonomia, especially orthostatic hypotension (OH), with cognitive impairment and dementia as potential biomarkers to help stratify PD patients according to their risk of progression to dementia may lead to improvement in possible treatment strategies and decrease disease burden.