Progressive dysexecutive syndrome in Alzheimer’s disease

Takeaway

  • Early-onset progressive dysexecutive syndrome (PDS) with biomarkers for Alzheimer’s disease (AD) should be explored as an atypical clinical phenotype that can be due to AD.

Why this matters

  • Atypical clinical phenotypes of AD without specific diagnostic criteria are often encountered, leading to delayed- or misdiagnosis.

  • Identifying atypical phenotypes might facilitate earlier and accurate diagnosis and treatment, with direct implications for patient outcomes.