Resistance to pain-relief in women with dysmenorrhea


  • In women with dysmenorrhea, there is significant correlation between serum naproxen levels and reduction in pain suggesting that malabsorption may contribute to lack of therapeutic efficacy.

Why this matters

    Non-steroidal anti-inflammatory (NSAID) resistance may prompt physicians to turn to more potentially harmful alternatives such as opioids and corticosteroids; however, the role of malabsorption as a contributor to NSAID resistance is poorly understood.