Risk for Parkinson’s disease among those with hyperechogenicity, hyposmia, or mild parkinsonism

Takeaway

  • A prospective cohort study found that elderly individuals with midbrain hyperechogenicity, hyposmia, or mild parkinsonism symptoms have an increased risk of developing Parkinson’s disease (PD) after long-term follow-up 5 and 10 years later.

Why this matters

    The assessed risk factors were associated with elevated risk for PD, but positive predictive values were too low to predict PD on an individual level; these risk factors may be suitable for inclusion in step-wise screening (for example, after history taking but before costly markers such as dopamine transporter imaging).