When is the best time to initiate preventive treatment in premanifest Huntington’s disease?

The stage of premanifest Huntington’s disease (preHD) at which brain function is normal, but sensitive measures of neurodegeneration are starting to rise, may be the best time to apply interventions to delay or prevent further neurodegeneration while function is intact, specialists have reported. This stage occurs approximately 24 years from predicted onset.

Researchers at the Huntington's Disease Centre, University College London, UK, identified this timepoint and also aimed to identify the best measures to use as endpoints in future therapeutic trials. The study participants were 64 young adults with preHD, approximately 24 years from predicted clinical onset, and 67 matched controls.